Comprehensive Characterization of Conformational Dynamics in Risk and Resilience Alleles of Apolipoprotein E for Alzheimer’s Disease using Long‐Time Scale Molecular Simulations And Graph Neural Networks
We have identified putative risk or resilience conformational states in APOE, which may have implications for therapeutic discovery.
Authors
- Feixiong Cheng (ORCID: https://orcid.org/0000-0002-1736-2847)
- William Robert Martin (ORCID: https://orcid.org/0000-0003-0616-0462)
Institutions
- Cleveland Clinic (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089342
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00