A common microvascular endophenotype in head injuries and Alzheimer’s disease

Based on transcriptomic analysis on cerebrovascular scRNA-seq datasets, we identified a common molecular signature between mTBI and aging vasculature, involving a novel transmembrane protein gene Tmem252. Tmem252 upregulation in brain endothelial cells may represent a shared endophenotype of microvascular injuries in different pathological conditions, and therapeutically targeted for treating BBB breakdown and vascular dysfunctions.