Rare genetic variation in fibronectin 1 (<i>FN1</i>) protects against <i>APOE</i> ɛ4 in Alzheimer’s Disease
The vascular deposition of the ECM components FN1 and COL6A2 are increased in APOEε4 carriers. Rare variant in FN1 protect against APOEε4-mediated pathogenesis in AD. We propose a new disease mechanisms and potential therapeutic intervention targets for vascular contribution to dementia to mitigate the risk of developing AD.
Authors
- Martin Medrano (ORCID: https://orcid.org/0000-0003-3673-9088)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Dörthe Jülich
- Patricia Recio
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- Tamil Iniyan Gunasekaran (ORCID: https://orcid.org/0000-0002-8639-5060)
- Hüseyin Tayran
- Çağhan Kızıl (ORCID: https://orcid.org/0000-0002-8164-9762)
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Elanur Yılmaz (ORCID: https://orcid.org/0000-0001-7045-5068)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Tal Nuriel (ORCID: https://orcid.org/0000-0002-5252-8048)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Scott A. Holley (ORCID: https://orcid.org/0000-0001-5299-1174)
- Prabesh Bhattarai (ORCID: https://orcid.org/0000-0003-2991-5514)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Delaney Flaherty
- Bengisu Turgutalp Uzrek
Institutions
- NewYork–Presbyterian Hospital (US)
- Uniformed Services University of the Health Sciences (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- Columbia University Irving Medical Center (US)
- WinnMed (US)
- Instituto Tecnológico de Santo Domingo (DO)
- Yale University (US)
- Institute on Aging (US)
- Mayo Clinic in Florida (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089111
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00