A Challenging Case of Lewy Body Disease in a Symptomatic Patient Negative for Phosphorylated Alpha‐Synuclein: Implications for Lewy Body Spectrum Disorders

This case challenges the long-held notion that phosphorylated-α-syn is an essential component of LBs especially needed to cause clinical symptoms. The absence of phosphorylated-α-syn LBs in a symptomatic patient suggests that additional proteins, or alternative mechanisms of abnormal protein accumulation may be involved in disease pathogenesis. This report highlights the complexity of LB pathology and emphasizes the need for continued research to unravel the diverse protein aggregates and mechanisms underlying LB formation and neurodegeneration. By expanding our understanding of LB spectrum disorders, we can enhance diagnostic procedures and facilitate the development of targeted therapies for patients with these diverse and debilitating conditions.