Reducing tau acetylation rescues cognitive deficits in a mouse model of traumatic brain injury‐induced acceleration of Alzheimer’s disease
TBI accelerates onset of AD-like pathologies in 5xFAD mice. Preliminary evidence shows that pharmacologically reducing acetylated tau rescues TBI-induced cognitive deficits in 5xFAD mice.
Authors
- Kathryn Franke (ORCID: https://orcid.org/0000-0002-3038-2826)
- Bindu D. Paul (ORCID: https://orcid.org/0000-0002-1862-6103)
- Aristotle Apostolakis
- Jung A. Woo (ORCID: https://orcid.org/0000-0002-9194-1361)
- Sarah Barker
- Kalyani Chaubey (ORCID: https://orcid.org/0000-0002-6378-6739)
- Salvatore G. Caradonna (ORCID: https://orcid.org/0000-0001-9192-2630)
- Preethy S. Sridharan (ORCID: https://orcid.org/0000-0001-7692-6342)
- Sunil Jamuna Tripathi (ORCID: https://orcid.org/0000-0001-9107-2437)
- Andrew A. Pieper (ORCID: https://orcid.org/0000-0001-6299-6577)
- Suwarna Chakraborty (ORCID: https://orcid.org/0000-0001-9456-4322)
- Brigid Wilson (ORCID: https://orcid.org/0000-0003-2966-2940)
- David E. Kang (ORCID: https://orcid.org/0000-0002-7132-821X)
- Coral J. Cintrón-Pérez (ORCID: https://orcid.org/0000-0003-2160-4244)
- Edwin Vázquez‐Rosa (ORCID: https://orcid.org/0009-0005-4508-5217)
- Sofia Corella
- Ryan Kornblit
- Lijun Dou
- Li Gan
- Min‐Kyoo Shin (ORCID: https://orcid.org/0000-0003-2232-3882)
- Feixiong Cheng
Institutions
- Cleveland Clinic (US)
- Seoul National University (KR)
- Johns Hopkins University (US)
- Cornell University (US)
- Brown University (US)
- University Hospitals of Cleveland (US)
- Johns Hopkins Medicine (US)
- MIND Research Institute (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091710
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00