Deciphering Iron Redox Changes in Alzheimer’s Disease using DNAzyme Sensors that can Simultaneously Monitor Fe<sup>2+</sup> and Fe<sup>3+</sup>
We have developed highly selective sensors for simultaneously imaging Fe<sup>2+</sup> and Fe<sup>3+</sup>. By integrating these sensors with immunohistochemistry, we have identified correlations between Fe redox, amyloid plaques, and neurodegeneration in AD mice. Our sensors can offer deep insights into the detailed mechanism of ferroptosis and its role in AD.
Authors
- Ryan J. Lake (ORCID: https://orcid.org/0000-0002-5552-0228)
- Liviu M. Mirica (ORCID: https://orcid.org/0000-0003-0584-9508)
- Zhenglin Yang (ORCID: https://orcid.org/0000-0003-2743-5779)
- Shanni Hong (ORCID: https://orcid.org/0000-0001-6078-1716)
- Seyed‐Fakhreddin Torabi (ORCID: https://orcid.org/0000-0003-1643-3583)
- Zhengxin Yu (ORCID: https://orcid.org/0000-0002-3592-9704)
- Yuting Wu (ORCID: https://orcid.org/0000-0003-3196-5916)
- Yi Lu (ORCID: https://orcid.org/0000-0003-1221-6709)
- Laura Fonken
Institutions
- University of Illinois Urbana-Champaign (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088440
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00