The SMOC1 proteomics network M42 controls multiple signaling modalities, brain homeostasis and toxicity in fly Alzheimer’s disease models
The M42 protein module contains multiple proteins with links to AD. Multiple M42 proteins interact with specific AD triggers including SMOC1, wnt and TGF-β signaling components. The genetics, proteomics, and cell biological data combine to support a mechanistic hypothesis where changes in SMOC1 levels disrupt critical signaling pathways leading to disruptions in metabolism affecting neuronal function.
Authors
- Joshua M Shulman (ORCID: https://orcid.org/0000-0001-6382-5841)
- Juan Botas (ORCID: https://orcid.org/0000-0001-5476-5955)
- Ismael Al‐Ramahi (ORCID: https://orcid.org/0000-0002-1275-1114)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Bismark K Amoh
- Aditi Sai Marella
- David Li‐Kroeger (ORCID: https://orcid.org/0000-0001-6473-7691)
- Nathaniel Smith
- Saathwik Saladi
Institutions
- Emory University (US)
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
- Brandeis University (US)
- Rice University (US)
- Des Moines University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089554
- Citations
- 1
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.45