Deletion of α5 integrin in endothelial cells ameliorates age–associated cognitive decline and increases survival in mice

Observations from Y maze and open field tests suggest that α5-EC-KO mice have improved spatial memory and less anxiety behavior when compared to aged-matched WT mice. Moreover, the Kaplan-Meier curves depict a greater probability of survival for aged α5-EC-KO mice. Thus, α5 integrin expression may significantly influence age-related cognitive decline. Preliminary data suggests that inhibition of α5 integrin may improve symptoms of age-associated cognitive impairment.