Apolipoprotein E4 contributes to Alzheimer’s disease neuropathology in Down syndrome
APOE4/4 further accelerates and enhances AD neuropathologies in people with DS. Understanding the molecular and cell type-specific changes caused by APOE4 as compared to APOE3 in DS-AD will aid in the development of more targeted and proactive therapies to alleviate dementia risk in individuals with DS.
Authors
- Hector Esquer (ORCID: https://orcid.org/0000-0002-1911-1523)
- Breanna Dooling
- Daphne Quang (ORCID: https://orcid.org/0000-0001-9064-6531)
- Noah R. Johnson (ORCID: https://orcid.org/0000-0002-0969-0066)
- Molishree Joshi (ORCID: https://orcid.org/0000-0003-4109-5918)
- Huntington Potter
- Rose Summers
Institutions
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091727
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00