Repeated infection by cytomegalovirus induces neuroinflammation and compromises BBB integrity
A history of intermittent CMV infection led to significant increases in reactive astrocytic and microglial activity in conjunction with compromised BBB integrity in the hippocampus. These results together provide a framework for how infection burden alters neurobiology and contributes to the progression of cognitive decline.
Authors
- Nayide Barahona-Guzmán (ORCID: https://orcid.org/0000-0003-3559-6900)
- Elizabeth B. Engler-Chiurazzi (ORCID: https://orcid.org/0000-0002-7656-1192)
- Kevin J. Zwezdaryk (ORCID: https://orcid.org/0000-0001-8915-0715)
- Sara Morris (ORCID: https://orcid.org/0000-0002-7701-334X)
- Kerry Willis (ORCID: https://orcid.org/0000-0002-0885-1307)
- Mark A. Harrison (ORCID: https://orcid.org/0000-0001-5586-0655)
- Lucas P. Garfinkel
- Hanyun Wang (ORCID: https://orcid.org/0000-0002-4864-6500)
- Advaith Subramanian
- Miayla Marcus
Institutions
- Tulane University (US)
- Xavier University of Louisiana (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093005
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00