Inhibition of thrombin signaling after traumatic brain injury improves neurobehavioral dysfunction in 5xFAD mice
These findings indicate that there is chronic cerebrovascular dysfunction in 5xFAD mice that can be exacerbated by FPI and highlight the potential for targeting thrombin and related signaling processes for mitigating these effects after injury.
Authors
- Jaclyn Iannucci (ORCID: https://orcid.org/0000-0002-7431-7882)
- Paula Grammas (ORCID: https://orcid.org/0000-0002-2636-3550)
- Lee A. Shapiro (ORCID: https://orcid.org/0000-0003-0575-7662)
- Shreya Bandopadhyay
- Victoria Arismendi
Institutions
- Texas A&M Health Science Center (US)
- Roskamp Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091625
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00