Hyperhomocysteinemia and hypertension exacerbate cerebrovascular dysfunction and Alzheimer’s Disease pathology in the Tg2576 mouse model of amyloidosis
CVRFs potentiate increases in specific cerebrovascular and angiogenic deficits in Tg2576 mice. This study revealed new molecular mechanisms and druggable targets through which amyloidosis, Hhcy and HTN additively act to produce vascular damage and dysfunction in AD.
Authors
- Silvia Fossati (ORCID: https://orcid.org/0000-0002-2047-222X)
- Ashley M Carey
Institutions
- Temple University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090484
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00