Autophagy Deficits Underly Selective Neuronal Vulnerability to Alpha Synuclein Fibrils in Alzheimer’s and Parkinson’s iPSC Derived Neurons
These preliminary results show relative vulnerability of AD against PD cortical neurons, and dopaminergic against cortical neurons to alpha-synuclein aggregates for the first time. These suggest the selective vulnerability to proteinopathy in these diseases is reflected by the iPSC neuronal model and support the notion that cell intrinsic factors like autophagy drive vulnerability.
Authors
- Bryan Ng (ORCID: https://orcid.org/0000-0002-6819-0176)
- Nora Bengoa‐Vergniory (ORCID: https://orcid.org/0000-0002-3700-0464)
- Richard Wade‐Martins (ORCID: https://orcid.org/0000-0001-6691-580X)
- Rachel Heon‐Roberts (ORCID: https://orcid.org/0000-0001-9723-2227)
- Becky C. Carlyle (ORCID: https://orcid.org/0000-0003-1491-3217)
- Ajantha Abey (ORCID: https://orcid.org/0000-0003-0484-8001)
Institutions
- Agency for Science, Technology and Research (SG)
- University of Oxford (GB)
- Achucarro Basque Center for Neuroscience (ES)
- Parkinson's UK (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087271
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00