Variant‐to‐function mapping of late‐onset Alzheimer’s disease GWAS loci in human microglial models implicates <i>RTFDC1</i> as an effector gene at the <i>CASS4</i> locus
We implicate rs6024870 and RTFDC1 as a SNP-effector gene pair at the AD 'CASS4' GWAS locus, and the gene product is directly involved in driving a reduction in DNA DSB clearance.
Authors
- Alessandra Chesi (ORCID: https://orcid.org/0000-0002-0954-7446)
- Kieona Cook
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Elisabetta Manduchi (ORCID: https://orcid.org/0000-0002-4110-3714)
- Andrew Brown (ORCID: https://orcid.org/0000-0002-8087-3033)
- Andrew D. Wells (ORCID: https://orcid.org/0000-0002-3630-2145)
- James A. Pippin (ORCID: https://orcid.org/0000-0002-6850-8164)
- Struan F.A. Grant (ORCID: https://orcid.org/0000-0003-2025-5302)
- Kenyaita M. Hodge
- Elizabeth A. Burton (ORCID: https://orcid.org/0000-0002-8376-9282)
- Chun-Hung Su (ORCID: https://orcid.org/0000-0003-4003-008X)
- Mariana Argenziano (ORCID: https://orcid.org/0000-0002-2825-581X)
- Stewart A. Anderson (ORCID: https://orcid.org/0000-0002-7655-5016)
- Molly Ridler
- Gerard Schellenberg
Institutions
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089683
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25