Plasma biomarkers of vascular injury and cerebrovascular reactivity in <i>APOE4</i> carriers
Findings suggest that elevated levels of vascular injury markers are associated with deficits in cerebral vasoconstriction, particularly in APOE4 carriers at genetic risk for Alzheimer's disease. SAA, VCAM-1 and ICAM-1 are known to be involved in inflammation and endothelial dysfunction, and elevated levels are associated with cerebrovascular resistance and cognitive impairment. Our findings suggest that APOE4 carriers may be particularly vulnerable to these pathophysiological processes. Further longitudinal studies may elucidate whether inflammation and endothelial dysfunction precede or precipitate CVR deficits and contribute to cognitive decline in APOE4 carriers.
Authors
- Daniel A. Nation (ORCID: https://orcid.org/0000-0002-9123-0658)
- Fatemah Shenasa (ORCID: https://orcid.org/0000-0001-9030-4857)
- Allison C Engstrom (ORCID: https://orcid.org/0000-0002-4676-0430)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- John Paul M Alitin (ORCID: https://orcid.org/0009-0001-5494-9639)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Amy Nguyen (ORCID: https://orcid.org/0000-0002-5939-9306)
- Arunima Kapoor (ORCID: https://orcid.org/0000-0003-4622-8951)
- Isabel J. Sible (ORCID: https://orcid.org/0000-0003-3922-0628)
- Aimée Gaubert (ORCID: https://orcid.org/0000-0001-6812-522X)
- David Bradford (ORCID: https://orcid.org/0000-0002-9611-0479)
- Anisa Marshall (ORCID: https://orcid.org/0000-0001-5457-2520)
- Kathleen E. Rodgers (ORCID: https://orcid.org/0000-0002-7994-8894)
Institutions
- University of Southern California (US)
- University of Arizona (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087589
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00