C9orf72 repeat expansions increase risk for secondary symptom development in amyotrophic lateral sclerosis and behavioral‐variant frontotemporal degeneration
These findings highlight the need for clinician vigilance to detect the onset of secondary cognitive-behavioral and motor symptoms in patients carrying a C9orf72 repeat expansion, regardless of primary phenotype, and may warrant dual referrals between cognitive and neuromuscular clinics in these cases.
Authors
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Vivianna M. Van Deerlin (ORCID: https://orcid.org/0000-0002-7400-9097)
- Defne A. Amado (ORCID: https://orcid.org/0000-0001-6202-3900)
- Sharon Xiangwen Xie (ORCID: https://orcid.org/0000-0002-7886-4103)
- Eddie B Lee
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- Laynie Dratch (ORCID: https://orcid.org/0000-0002-2179-3199)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Colin Quinn (ORCID: https://orcid.org/0000-0003-0618-5854)
- Lauren Elman (ORCID: https://orcid.org/0000-0003-4706-950X)
- Michael Baer (ORCID: https://orcid.org/0009-0001-3739-4344)
- Barbara E. Spencer (ORCID: https://orcid.org/0000-0002-1685-2967)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090459
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00