The role of impaired oxidative base lesion repair in Alzheimer’s disease
The repair of oxidative DNA damage is critical for processes associated with AD pathogenesis, in particular neuroinflammation and important to maintain cognitive function. AD patient-derived vascularized cerebral organoids are immunocompetent and recapitulate AD pathology which will be advantageous to translate findings from mice to humans.
Authors
- Andreas Abentung (ORCID: https://orcid.org/0000-0003-4541-7865)
- Emily E Karabeika
- Teri Sakshaug
- Magnar Bjørås (ORCID: https://orcid.org/0000-0001-8759-1170)
- Milena A. Egiazarian
- Katja Scheffler (ORCID: https://orcid.org/0000-0002-1734-7807)
- Sigrid Botne Sando (ORCID: https://orcid.org/0000-0002-2864-0240)
- Gøril Rolfseng Grøntvedt (ORCID: https://orcid.org/0000-0003-2057-6683)
- Priyanka R Hanumaihgari
Institutions
- Oslo University Hospital (NO)
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090686
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00