Association of Neuropsychiatric Symptoms and General Psychopathology with Markers of Neurodegeneration in the General Population
Various neuropsychiatric symptoms and a generally higher level of psychopathology are associated with poorer cognitive performance, grey matter atrophy, and WMH burden, even in adults without a psychiatric diagnosis. However, we did not find direct evidence of neuroaxonal injury, as indicated by the absence of an association with NfL.
Authors
- Folgerdiena M. de Vries
- Ulrich Ettinger (ORCID: https://orcid.org/0000-0002-0160-0281)
- Monique M.B. Breteler (ORCID: https://orcid.org/0000-0002-0626-9305)
- Rika Etteldorf (ORCID: https://orcid.org/0009-0008-6317-7934)
Institutions
- University of Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092340
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00