Mitochondrial DNA depletion induces AD like phenotypes in neuronal and glial cells
mtDNAcn reduction can lead to AD pathological hallmarks including changes in Aβ secretion, tau homeostasis, and glial cell phenotypes. mtDNAcn reduction impairs mitochondrial respiration in glial cells, which affects the production of cytokines and leads to cell senescence. Cytokines released by glial cells with reduced mtDNAcn affected neuronal expression of AD-related genes.
Authors
- Wen Yi See
- Anysja Roberts (ORCID: https://orcid.org/0009-0009-6247-0175)
- Judy Pa (ORCID: https://orcid.org/0000-0002-5788-9352)
- Shea J. Andrews (ORCID: https://orcid.org/0000-0002-1921-9470)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Colton R Lysaker
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Carmen Romero Molina
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Caleb A. Gilmore
- Yiyuan Liu (ORCID: https://orcid.org/0000-0002-9008-9170)
Institutions
- University of Southern California (US)
- Allen Institute for Brain Science (US)
- University of Kansas (US)
- University of California, San Francisco (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- National University (US)
- University of Kansas Medical Center (US)
- Pediatrics and Genetics (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089073
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00