Analysis of ADNI phenotypic and mulit‐omic data identifies the role of microglial debris and lipid processing in Alzheimer’s Disease transition
Our analysis provides evidence for the importance of lipid droplet saturation coinciding with correlational changes in CSF proteins and plasma lipids, occurring in individuals transitioning from cognitively normal to MCI. We connected microglial AD GWAS loci to differences in the progression rates at this transition. These results have potential clinical relevance for predicting progression rate at MCI diagnosis, and inform our understanding of the role of GWAS loci in key transitions.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Jennifer A. Rohrs (ORCID: https://orcid.org/0000-0001-5151-2135)
- Tom Paterson (ORCID: https://orcid.org/0000-0002-8530-1376)
- Cory C. Funk (ORCID: https://orcid.org/0000-0002-5229-9011)
Institutions
- Institute for Systems Biology (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092897
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00