In vivo TurboID labeling for paired proteomic and transcriptomic profiling of neurons and astrocytes
Together, these results validate the CIBOP approach to capturing the cortical Aldh1l1-positive astrocytic and Camk2a-positive neuronal proteome and transcriptome. Our innovative in vivo cell type-specific and native-state dual-omics approach provides complementary transcriptomic and proteomic information that can extend to AD models to investigate disease mechanisms, discover new biomarkers, and identify therapeutic targets.
Authors
- Pritha Bagchi (ORCID: https://orcid.org/0000-0001-7229-9476)
- Steven A. Sloan (ORCID: https://orcid.org/0000-0001-7769-7684)
- Srikant Rangaraju (ORCID: https://orcid.org/0000-0003-2765-1500)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Prateek Kumar (ORCID: https://orcid.org/0000-0001-5875-4065)
- Ruth S. Nelson
- Christina C. Ramelow (ORCID: https://orcid.org/0000-0001-5443-1074)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Maureen M. Sampson (ORCID: https://orcid.org/0000-0003-1536-3229)
- Lihong Cheng (ORCID: https://orcid.org/0000-0002-2522-4831)
- Sneha Malepati (ORCID: https://orcid.org/0009-0007-1182-2471)
- Duc M. Duong (ORCID: https://orcid.org/0000-0002-3325-9233)
- Hailian Xiao (ORCID: https://orcid.org/0000-0002-3796-4693)
- Qi Quo
Institutions
- Emory University (US)
- Yale University (US)
- Institute for Neurodegenerative Disorders (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091147
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00