Association between known Alzheimer’s disease risk genetic variants and hippocampal atrophy along the Alzheimer’s disease continuum in a Korean cohort
Our study identified associations of rs6966331 in EPDR1 and rs2242595 in MYO15A with hippocampal volume in Korean older adults, and these associations were independent of cerebral Aβ deposition and APOE4 carrier status. These findings suggest that these AD-related loci may contribute to the development of AD dementia via Aβ-independent neurodegeneration.
Authors
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Hye‐Jin Ahn (ORCID: https://orcid.org/0000-0002-0085-9566)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Yun‐Sang Lee
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Yen‐Ning Huang
- Margaret A Pericak‐Vance
Institutions
- Seoul National University (KR)
- University of Miami (US)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Dr. John T. Macdonald Foundation (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092461
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00