Deciphering Microglial Contributions to Amyloid and Tau Pathology in Diverse Genetic Contexts

We expect our strategy of incorporating humanized amyloid and tau into genetically diverse mouse strains will significantly improve the alignment of neuroimmune responses in mouse to human AD. This will give the AD field a new way to determine mechanisms, identifying critical genes and pathways in early in disease onset or progression. Furthermore, this may pave the way for the development of microglia-based therapies to reduce or prevent tau propagation and spreading in AD and related dementias.