Exploring the Relationship Between Adipose Tissue and Alzheimer’s Disease Pathogenesis
Overall, our study demonstrate a novel important crosstalk between Alzheimer´s disease and obesity/diabetes type II through visceral adipose cells and a differential effect on tau and Aβ pathology mediated by an activated immune response. This study was supported by Minister of Science and Innovation grant PID2019-108911RA-100 (D.B.V.), Alzheimer's Association grant AARG-22-9282/9, Beatriz Galindo program BAGAL18/00052 (D.B.V.), University of Malaga grant PPIT.UMA.B1-2021_32(LTE) and Institute of Health Carlos III (ISCiii) grant PI18/01557 (A.G.) co-financed by FEDER funds from European Union.
Authors
- Juana Andreo‐Lopez (ORCID: https://orcid.org/0000-0003-2180-0560)
- David Baglietto‐Vargas (ORCID: https://orcid.org/0000-0003-1441-3175)
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Miriam Bettinetti‐Luque (ORCID: https://orcid.org/0009-0002-5177-9264)
- Laura Trujillo‐Estrada (ORCID: https://orcid.org/0000-0001-6696-4505)
- Elisabeth Sánchez‐Mejías
- Celia Da Cunha
- Antonia Gutiérrez (ORCID: https://orcid.org/0000-0002-6264-6152)
- Cynthia Campos‐Moreno
- Ivan Fatuarte‐Juli
- Mario Morales‐Cabello
Institutions
- University of California, Irvine (US)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092413
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Universidad de Málaga
- European Commission
- Instituto de Salud Carlos III