Loss of Alzheimer’s disease risk factor <i>BIN1</i> from inhibitory neurons induces network hyperexcitability
Bin1 loss from inhibitory neurons led to increased seizure susceptibility, similar to the pan-neuronal loss of Bin1, suggesting that loss of Bin1 from inhibitory neurons drives the effect of global loss of Bin1. Overall, this study contributes to our understanding of how BIN1 regulates network hyperexcitability at a cell-type-specific level.
Authors
- M. Natalie Davis
- Yuliya Voskobiynyk (ORCID: https://orcid.org/0000-0003-4169-3002)
- J. Nicholas Cochran (ORCID: https://orcid.org/0000-0002-9852-5504)
- Nancy V. N. Carullo (ORCID: https://orcid.org/0000-0001-9197-5046)
- Erik D. Roberson (ORCID: https://orcid.org/0000-0002-1810-9763)
- Jeremy J. Day (ORCID: https://orcid.org/0000-0002-7361-3399)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087069
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00