Identification of differentially expressed genes in post‐mortem tissue from African American Alzheimer disease cases and controls
This largest-ever (to our knowledge) gene expression study of AD in postmortem brain tissue from AA donors implicates many more genes as having a role in AD in this population than previously identified in genome-wide association studies and provides insight into trans-ancestry differences risk for AD.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Margaret E. Flanagan (ORCID: https://orcid.org/0009-0008-7078-3545)
- Matthew P. Frosch (ORCID: https://orcid.org/0000-0002-3940-9861)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Shih‐Hsiu J. Wang (ORCID: https://orcid.org/0000-0002-0358-8159)
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Lee‐Way Jin (ORCID: https://orcid.org/0000-0001-9729-1032)
- Mark W. Logue (ORCID: https://orcid.org/0000-0001-9347-7892)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Erin Franklin (ORCID: https://orcid.org/0000-0002-6614-4109)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Ann Carolyn McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Adam Labadorf (ORCID: https://orcid.org/0000-0002-0753-8992)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Eddie B Lee
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Nicholas K. O’Neill (ORCID: https://orcid.org/0000-0002-9953-9940)
- Carol A. Miller
- Richard Mayeux
- Marla Gearing
Institutions
- Boston University (US)
- Northwestern University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- VA Boston Healthcare System (US)
- WinnMed (US)
- Massachusetts General Hospital (US)
- VA New England Healthcare System (US)
- National Center for PTSD (US)
- Duke Medical Center (US)
- Prevent Alzheimer’s Disease 2020 (US)
- Institute on Aging (US)
- Mayo Clinic in Florida (US)
- University of California Davis Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091575
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00