Sex Differences in Cerebrovascular Reactivity to Hypercapnia in Older Adults
Older men exhibited lower cerebral vasodilatory responses to hypercapnia relative to women, independent of the effects of aging. These results are consistent with prior findings suggesting that women have higher cerebral blood flow relative to age-matched men. Findings could suggest older women are at increased risk of vascular brain injury and resulting cognitive decline, and inform future studies of CVR as a marker of risk in this population.
Authors
- Daniel A. Nation (ORCID: https://orcid.org/0000-0002-9123-0658)
- Fatemah Shenasa (ORCID: https://orcid.org/0000-0001-9030-4857)
- Allison C Engstrom (ORCID: https://orcid.org/0000-0002-4676-0430)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Trevor Lohman (ORCID: https://orcid.org/0000-0002-9634-702X)
- John Paul M Alitin (ORCID: https://orcid.org/0009-0001-5494-9639)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Arunima Kapoor (ORCID: https://orcid.org/0000-0003-4622-8951)
- Isabel J. Sible (ORCID: https://orcid.org/0000-0003-3922-0628)
- Aimée Gaubert (ORCID: https://orcid.org/0000-0001-6812-522X)
- Anisa Marshall (ORCID: https://orcid.org/0000-0001-5457-2520)
Institutions
- University of Southern California (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093323
- Citations
- 2
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.84