The relationship between dyadic perspective in subjective reports and objective cognitive decline in preclinical Alzheimer's
Aβ-pathology was linked to memory, but not global obj-SCD, in participants not yet meeting MCI criteria. Subjective reports from informants showed greater effect sizes than reports from participants and were associated to memory and global obj-SCD. The participant-informant discrepancy observed for memory obj-SCD and its association to AD-related impairment suggested that participants with objective memory problems might not be fully aware of these subtle changes, highlighting the relevance of tracking dyadic reports in preclinical Alzheimer's.
Authors
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Nina Gramunt (ORCID: https://orcid.org/0000-0003-3962-1253)
- Alba Cañas (ORCID: https://orcid.org/0000-0001-5664-6941)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- José Luís Molinuevo (ORCID: https://orcid.org/0000-0003-0485-6001)
- Paula Marne
- Lidia Canals‐Gispert (ORCID: https://orcid.org/0000-0002-7025-2102)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
Institutions
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Global Brain Health Institute (US)
- Hospital del Mar Research Institute (ES)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087054
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00