An endolysosome pathway specific polygenic risk score for Alzheimer Disease predicts cell‐type specific transcriptomic and morphological phenotypes
Taken together, our data suggests that AD risk loci implicating genes within the endolysosomal system do in fact impact the cellular ELN, giving more confidence to the pathogenic relevance of "endolysosomal" risk loci. Dysfunction of endolysosomal pathways likely contributes to AD pathogenesis in LOAD and may highlight more specific points of intervention. Pathway-specific polygenic risk scores can enhance our understanding of the complex mechanisms contributing to AD and pave the way for more specific targeted therapies in the clinic.
Authors
- Sam Strohbehn
- Elizabeth Blue (ORCID: https://orcid.org/0000-0002-0633-0305)
- Corbin S.C. Johnson (ORCID: https://orcid.org/0000-0001-9616-5755)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Jessica E. Young (ORCID: https://orcid.org/0000-0003-2106-0339)
- Ali Shojaie (ORCID: https://orcid.org/0000-0001-8846-3533)
- Suman Jayadev (ORCID: https://orcid.org/0000-0003-3164-9665)
- Sainath Mamde
- Gwenn A. Garden (ORCID: https://orcid.org/0000-0002-8753-6515)
- Wei Sun (ORCID: https://orcid.org/0000-0002-6350-1107)
- Katherine E. Prater (ORCID: https://orcid.org/0000-0001-8615-207X)
- Alexandra Cochoit (ORCID: https://orcid.org/0009-0005-8022-2459)
- Shannon E. Rose
Institutions
- University of North Carolina at Chapel Hill (US)
- California Institute for Regenerative Medicine (US)
- University of Washington (US)
- University of California San Diego (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087986
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00