Effects of lifestyle factors on Alzheimer’s disease symptoms in adults with Down syndrome
Lifestyle activities moderated the association between Aβ chronicity and AD symptoms. Participants who had active lifestyles with more cognitive, social, physical, and vocational activities evidenced fewer AD symptoms (i.e., less cognitive impairment) given similar Aβ chronicity values than participants who engaged in fewer activities. This study was limited to cross-sectional associations. Future longitudinal research should tease out time-ordered effects. Modifiable lifestyle factors may allow adults with DS to maintain cognitive functioning for longer in the face of early AD pathology.
Authors
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Christy Hom (ORCID: https://orcid.org/0000-0003-0266-0961)
- Emily K. Schworer (ORCID: https://orcid.org/0000-0002-5309-339X)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086288
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00