Sex‐dependent APOE4 neutrophil‐microglia interactions drive cognitive impairment in Alzheimer's Disease
These findings highlight the impact of peripheral immunity on AD pathology, provide a translational basis for precise targets for APOE ε4 carriers, and identify the biological rational for IL-17F blockade in females with cognitive impairment. These findings link neutrophil signature to sex and APOE4 as drivers of AD and emphasize the necessity for personalized therapeutic interventions for AD.
Authors
- Oleg Butovsky (ORCID: https://orcid.org/0000-0003-0186-8867)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087776
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00