Cognitive reserve influences symptom onset and longitudinal decline in Dominantly Inherited Alzheimer's Disease
CR significantly modifies both AAO and rate of clinical decline in DIAD. These findings highlight CR as a factor in AD progression and suggest potential avenues for intervention by enhancing CR to delay onset.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Alan E. Renton (ORCID: https://orcid.org/0000-0001-6702-8268)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Alisha Daniels (ORCID: https://orcid.org/0009-0001-1464-6465)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Ruijin Lu (ORCID: https://orcid.org/0000-0001-9356-6545)
- Andrew J. Aschenbrenner (ORCID: https://orcid.org/0000-0002-4317-7282)
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
- Chengjie Xiong (ORCID: https://orcid.org/0009-0003-8949-2629)
- John C. Morris
Institutions
- Allen Institute for Brain Science (US)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086295
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39