Commonalities in the lipid profile shift in ApoE ε4 risk variant and mild cognitive impairment highlight acyl chain remodeling
Our studies highlight the critical dysregulation of acyl chain remodeling in ApoEe4 carriers and MCI in human brain which could be modeled in mouse and cell models of disease. A coordinated lipid profile shift in both ApoEe4 carriers and MCI suggest pathological changes in lipid metabolism underly early disease and highlight lipid dyshomeostasis as a tractable target for early disease modifying intervention.
Authors
- Jason Mares
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Artur Lazarian
- Krista Minéia Wartchow (ORCID: https://orcid.org/0000-0003-4572-3600)
- William Jones Dartora (ORCID: https://orcid.org/0000-0002-6164-0031)
- Laura Beth McIntire (ORCID: https://orcid.org/0000-0002-9565-8889)
- Tal Nuriel (ORCID: https://orcid.org/0000-0002-5252-8048)
- Ana Paula Costa (ORCID: https://orcid.org/0000-0002-4632-038X)
Institutions
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Weill Cornell Medicine (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087508
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00