Expression of human tau in adult <i>Drosophila melanogaster</i> causes a sexually dimorphic sleep phenotype
Our results indicate that pathological tau expression in Drosophila melanogaster causes neurodegeneration and increase sleep in females. These results indicate that pathological tau may directly contribute to sleep disruption in humans and provides a new model system to further our understanding of the role of tau in neurodegeneration.
Authors
- Edmond N Mouofo (ORCID: https://orcid.org/0000-0003-1857-8751)
- Patrik Verstreken (ORCID: https://orcid.org/0000-0002-5073-5393)
- James H. Catterson (ORCID: https://orcid.org/0000-0003-4231-0114)
- Tara L. Spires‐Jones (ORCID: https://orcid.org/0000-0003-2530-0598)
Institutions
- UK Dementia Research Institute (GB)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088411
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00