Chimeric hippocampal organotypic slices enable the <i>in vitro</i> investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity
The developed chimeric OSCs model with engrafted human iPSC-microglia provides an ex vivo platform to investigate human iPSC-derived microglia within a physiologically relevant and functional brain network.
Authors
- Annelies Nonneman
- Sofie Swijsen
- Hervé Maurin (ORCID: https://orcid.org/0000-0001-9782-7589)
- Ping Shih (ORCID: https://orcid.org/0000-0002-2592-8273)
- Johanna Van Den Daele (ORCID: https://orcid.org/0000-0001-8879-4551)
- Winnok H. De Vos (ORCID: https://orcid.org/0000-0003-0960-6781)
- Jens Devoght (ORCID: https://orcid.org/0000-0002-7316-4343)
- Juan Diego Pita Almenar
- Andreas Ebneth
- Dirk Wuyts
Institutions
- Janssen (Belgium) (BE)
- University of Antwerp (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088649
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00