Retinal neurodegeneration and synaptic loss in relations to core‐proteinopathies and cognitive scores in MCI and AD patients
Our study reveals pronounced retinal neurodegeneration at pSer396-tau and Aβ<sub>42</sub> accumulation sites, coupled with increased retinal oxidative stress in MCI and AD patients. Elevated retinal ROS and pre-apoptotic cells may contribute to synaptic loss and neuronal death. These findings suggest that retinal synaptic loss and neurodegeneration may predict AD status.
Authors
- Keith L. Black (ORCID: https://orcid.org/0000-0002-0546-4934)
- Altan Rentsendorj (ORCID: https://orcid.org/0009-0001-4322-8107)
- Edward Robinson (ORCID: https://orcid.org/0000-0001-8262-2281)
- Bhakta Prasad Gaire (ORCID: https://orcid.org/0000-0002-9738-6493)
- Jean‐Philippe Vit (ORCID: https://orcid.org/0000-0001-5057-8554)
- Lon S. Schneider (ORCID: https://orcid.org/0000-0002-4636-6150)
- Dieu‐Trang Fuchs
- Maya Koronyo‐Hamaoui (ORCID: https://orcid.org/0000-0003-2864-8442)
- Debra Hawes (ORCID: https://orcid.org/0000-0001-5936-4835)
- Miyah R. Davis
- Ousman Jallow
- Yosef Koronyo
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Keck Hospital of USC (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087799
- Citations
- 1
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.40