Delivery of mRNA encoding an anti‐tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in neurons
IVT synthesised mRNA can be used to generate both functional full-length IgG antibodies and scFv intrabodies targeting tau. Our study highlights the utility of mRNA as an inexpensive and versatile delivery platform for antibody therapeutics.
Authors
- Alayna C. Caruso (ORCID: https://orcid.org/0000-0001-9926-9496)
- Rebecca M. Nisbet (ORCID: https://orcid.org/0000-0002-3751-9119)
- Laura J. Vella (ORCID: https://orcid.org/0000-0002-1869-6291)
- Ya Hui Hung (ORCID: https://orcid.org/0000-0002-5440-2764)
- Alicia Yong (ORCID: https://orcid.org/0009-0008-3114-5428)
- Patricia Wongsodirdjo
- Madeleine A. Lester
Institutions
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087103
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00