The influence of <i>APOE<sup>ε4</sup></i> on the pTau interactome in sporadic Alzheimer’s disease
Our study supports an influence of APOE genotype on pTau subcellular location in the human brain. These results are consistent with a facilitation of pTau progression in Aβ-affected brain regions of APOE<sup>ε4</sup> carriers, paving the way to the identification of potential new therapeutic targets.
Authors
- Geoffrey Pires (ORCID: https://orcid.org/0000-0002-7050-9844)
- Dominique Leitner (ORCID: https://orcid.org/0000-0002-1371-9861)
- Jackeline Ponce (ORCID: https://orcid.org/0000-0002-3886-9989)
- Arline Faustin (ORCID: https://orcid.org/0000-0002-1147-9665)
- Beatrix Ueberheide (ORCID: https://orcid.org/0000-0003-2512-0204)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Eleanor Drummond (ORCID: https://orcid.org/0000-0002-5466-4609)
- Evgeny Kanshin (ORCID: https://orcid.org/0000-0001-7142-4554)
- Manor Askenazi (ORCID: https://orcid.org/0000-0003-1646-833X)
- Manon Thierry
- Mitchell Marta Ariza
Institutions
- The University of Sydney (AU)
- N2 Biomedical (United States) (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091601
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00