Mosaic Loss of Chromosome Y in Peripheral Blood Cells from Whole‐Genome Sequencing and Alzheimer’s Disease in the Amish
We assessed the impact of mLOY in males on the risks of CI. We observed the same trend as reported in other European descent populations: mLOY increased with age and the higher sensitivity with WGS data compared with array-based data. We found that carriers of mLOY had an increased risk of impairment.
Authors
- Daniel A. Dorfsman
- Kristy Miskimen
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Leighanne R. Main (ORCID: https://orcid.org/0000-0002-8828-8066)
- Jason E. Clouse
- Sharlene D. Herington
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Yining Liu
- Sherri D. Hochstetler
- Alan J. Lerner (ORCID: https://orcid.org/0000-0001-9447-6154)
- Michael B. Prough
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Reneé A. Laux
- Paula Ogrocki
- Laura J. Caywood
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- Ping Wang (ORCID: https://orcid.org/0009-0005-8478-466X)
- Weihuan Wang (ORCID: https://orcid.org/0000-0002-1053-6859)
- Nicole M. Moore (ORCID: https://orcid.org/0000-0003-2012-3967)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Sarada L. Fuzzell
- Susan H. Slifer
- Larry D. Adams
- Audrey Lynn
- Margaret A Pericak‐Vance
- Alex V. Gulyayev
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089681
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00