Local ancestry in Apoe3: Friend or Foe?
Our preliminary data suggest that the LA surrounding APOE3 is associated with different effects on APOE expression compared to APOE4 allele. Further, within the same LA, we observed that, overall, the different cell types express less APOE in APOE3 carriers compared to APOE4 carriers. Altogether, this may provide additional insight into the regulatory mechanisms affecting APOE4 expression.
Authors
- Sandra Weıntraub (ORCID: https://orcid.org/0000-0003-2605-5205)
- Margaret E. Flanagan (ORCID: https://orcid.org/0009-0008-7078-3545)
- Juan I. Young
- Theresa Schuck
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Sofia Moura (ORCID: https://orcid.org/0000-0002-9000-2290)
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- Patrice L. Whitehead
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Katrina Celis
- Marla Gearing (ORCID: https://orcid.org/0000-0002-1959-7412)
- Margaret A. Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Regina Vontell (ORCID: https://orcid.org/0000-0002-2664-8265)
- Luciana Bertholim Nasciben (ORCID: https://orcid.org/0009-0002-1518-1409)
- David A. Davis (ORCID: https://orcid.org/0000-0002-9323-6180)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- David A. Bennett
- Joe Rivero
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- Emory University (US)
- Dr. John T. Macdonald Foundation (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091750
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00