Baseline regional amyloid distribution in relation to subsequent self‐ and informant‐rated apathy scores in community‐dwelling older adults

In a cohort of older adults who were cognitively unimpaired and nondepressed at baseline, higher initial cortical amyloid levels in the IT, precuneus, supramarginal, ACC, and mOFC regions were associated with greater informant-rated, but not self-rated, apathy approximately 8 years later. These results shed light on the neurobiology of apathy in older individuals and preclinical AD and emphasize the importance of obtaining both self- and informant-report when assessing new or worsening neuropsychiatric symptoms.