Investigating the effects of increasing O‐GlcNacylation in Alzheimer’s disease in the TgF344‐AD rat model
We report that increasing O-GlcNAcylation from 6-9 months in the TgF344-AD rats is reducing reactive astrocytes. While this could be beneficial to preserving their function and neuronal health, this work is still ongoing. We are working to increase our sample size, and to examine the locus coeruleus for changes in hyperphosphorylated tau and other biomarkers.
Authors
- Nateka L. Jackson (ORCID: https://orcid.org/0000-0001-7364-2440)
- Melissa L. Garcia (ORCID: https://orcid.org/0000-0002-1814-4227)
- Lori L. McMahon (ORCID: https://orcid.org/0000-0003-1104-6584)
Institutions
- Medical University of South Carolina (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093507
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00