Reduction of neurogranin protein correlates with increases of inflammasome proteins in post mortem cases of intermediate Alzheimer’s disease
The finding of a negative correlation between Ng and ASC speck protein expression in postmortem brains of AD suggests that the activation of inflammasome/ASC speck pathway may play an important role in synaptic degeneration in AD.
Authors
- Xiaoyan Sun (ORCID: https://orcid.org/0000-0002-0918-6273)
- Ayled Barreda (ORCID: https://orcid.org/0000-0003-0890-8729)
- W. Dalton Dietrich (ORCID: https://orcid.org/0000-0002-8732-4942)
- Tatjana Rundek (ORCID: https://orcid.org/0000-0002-7115-9815)
- Robert W. Keane (ORCID: https://orcid.org/0000-0003-4068-9511)
- Helen M. Bramlett (ORCID: https://orcid.org/0000-0002-8200-0973)
- Juan Pablo de Rivero Vaccari (ORCID: https://orcid.org/0000-0002-5460-8834)
- Regina Vontell (ORCID: https://orcid.org/0000-0002-2664-8265)
- David A. Davis (ORCID: https://orcid.org/0000-0002-9323-6180)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- University of Science and Technology of China (CN)
- University of Miami (US)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089239
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00