Pathological Associations with Rate of Progression of Frontotemporal Dementia
Taken together, these results suggest that increased rate of clinical progression may relate to increased burden of TDP-43 observed postmortem. The heterogeneity in the prognosis of FTLD may be driven by biological factors, such as disease activity. Further, FTLD-TDP (especially FTLD-GRN) may associate with faster progression. Biomarkers of FTLD-TDP and/or improved access to mutation testing may improve prognostication in the care of FTD.
Authors
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- Emma Rhodes (ORCID: https://orcid.org/0000-0002-9053-0114)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Eddie B Lee
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Rogan Magee
Institutions
- Institute for Neurodegenerative Disorders (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089185
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00