Temporal dynamics of microglial neuroprotection during chronic Aß ‐treatment in human iPSC‐derived 3D neurospheres
We here present a human 3D cell culture model allowing the formation of neurospheres and a chronic Aß stimulation protocol to mimic amyloidosis as a novel human AD in vitro model. Transplanting microglia at different time points during culture allows to study the temporal dynamics of neuroprotective properties of microglia presenting a unique novel approach to reveal new potential therapeutic pathways.
Authors
- Haakon B. Nygaard (ORCID: https://orcid.org/0000-0001-5085-4723)
- Sarah N. Ebert
- Brian A. MacVicar (ORCID: https://orcid.org/0000-0003-4596-4623)
- Declan Brennan
- Stefan Wendt (ORCID: https://orcid.org/0000-0002-8754-2464)
- Wenji Cai (ORCID: https://orcid.org/0009-0003-1127-6571)
- Ada J. Lin
Institutions
- University of British Columbia (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091584
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00