Inflammasome Signaling in Alzheimer’s Disease after Traumatic Brain Injury
Our findings establish a chronic dysfunctional inflammatory response in TBI with a genetic predisposition to AD that is not seen in TBI alone. This suggests a unique injury progression that is affected by genetic predisposition to AD that calls for specialized treatment. In addition, due to the increased inflammasome response seen in our results, our conclusions indicate a promising role for the inflammasome as a treatment target.
Authors
- Nadine Kerr
- W. Dalton Dietrich (ORCID: https://orcid.org/0000-0002-8732-4942)
- Robert W. Keane (ORCID: https://orcid.org/0000-0003-4068-9511)
- Helen M. Bramlett (ORCID: https://orcid.org/0000-0002-8200-0973)
- Juan Pablo de Rivero Vaccari (ORCID: https://orcid.org/0000-0002-5460-8834)
- Nathan H. Johnson (ORCID: https://orcid.org/0000-0002-4857-2273)
- Erika d. l. R. M. Cabrera Ranaldi (ORCID: https://orcid.org/0000-0002-0929-5883)
Institutions
- University of Miami (US)
- Bruce W. Carter VA Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089769
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00