Astrocyte reactivity and cerebral glucose hypermetabolism in early Alzheimer’s: insights from a longitudinal study in the TgF344‐AD rat model
Our findings suggest the presence of an early, transient phase of brain glucose hypermetabolism in TgF344-AD rats, consistent with observations in recent animal and human studies. This phenomenon seems to be closely linked to the astrocyte response, reflected in variations of crucial astrocyte proteins such as GFAP and S100B, along with an increase in the glutamate uptake by these cells. In contrast, neuronal, microglial and inflammatory markers did not exhibit changes during this timeframe.
Authors
- Patrı́cia Silva (ORCID: https://orcid.org/0000-0002-6613-9000)
- Jaderson Costa DaCosta (ORCID: https://orcid.org/0000-0001-6776-1515)
- Gianina Teribele Venturin (ORCID: https://orcid.org/0000-0001-7696-8219)
- MODEL AD
- Luiza Santos Machado (ORCID: https://orcid.org/0000-0001-8387-3832)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- Gabriela Lazzarotto (ORCID: https://orcid.org/0000-0001-8035-3639)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Peter Kunach (ORCID: https://orcid.org/0000-0001-7428-6812)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Samuel Greggio (ORCID: https://orcid.org/0000-0002-5187-0335)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
- Analı́a Lima (ORCID: https://orcid.org/0000-0002-1855-2327)
- Andréia Silva da Rocha (ORCID: https://orcid.org/0000-0003-1567-3374)
- Diogo O. Souza (ORCID: https://orcid.org/0000-0002-4322-0404)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Pedro Vidor
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Instituto do Cérebro (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092409
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00