The X‐chromosome in Alzheimer’s disease genetics, stratified by <i>APOE</i>*4 and sex
For the first time, we identified X-chromosome loci/variants differentially associated with AD risk across APOE*4 and/or sex. Our findings contribute to our understanding of the genetic etiology of AD, which in turn contributes to advancing personalized genetic medicine. Additional follow-up and replication work is in progress.
Authors
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Valerio Napolioni (ORCID: https://orcid.org/0000-0002-4378-6838)
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Michaël E. Belloy (ORCID: https://orcid.org/0000-0001-7748-9033)
Institutions
- Università di Camerino (IT)
- Washington University in St. Louis (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089714
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55