ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease
Our results demonstrate a previously unknown link between ABCA7 and NPY in regulation of synaptic integrity and neurogenesis in AD. We propose that ABCA7-dependent NPY is a resilience factor in vertebrate brains, and this reserve mechanism is impaired in AD.
Authors
- Nastasia Nelson
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Tamil Iniyan Gunasekaran (ORCID: https://orcid.org/0000-0002-8639-5060)
- Mehmet İlyas Coşacak (ORCID: https://orcid.org/0000-0003-2978-3902)
- Caghan Kizil
- Özkan İş (ORCID: https://orcid.org/0000-0003-4070-6756)
- Yuhao Min (ORCID: https://orcid.org/0000-0001-8775-8743)
- Hüseyin Tayran
- Zikun Yang (ORCID: https://orcid.org/0000-0002-8834-6377)
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Elanur Yılmaz (ORCID: https://orcid.org/0000-0001-7045-5068)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Prabesh Bhattarai (ORCID: https://orcid.org/0000-0003-2991-5514)
- Xue Wang (ORCID: https://orcid.org/0000-0001-5973-6686)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Rüya Merve Dogru
- Nada Kassara
- Min N Qiao
- Yiyi Ma (ORCID: https://orcid.org/0000-0002-3609-8877)
- Delaney Flaherty
Institutions
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- New York Hospital Queens (US)
- German Center for Neurodegenerative Diseases (DE)
- WinnMed (US)
- Institute on Aging (US)
- Mayo Clinic in Florida (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089273
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49