ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease

Our results demonstrate a previously unknown link between ABCA7 and NPY in regulation of synaptic integrity and neurogenesis in AD. We propose that ABCA7-dependent NPY is a resilience factor in vertebrate brains, and this reserve mechanism is impaired in AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.089273
Citations
2
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.49
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article

ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease

Nastasia Nelson, Giuseppe Tosto, Joseph S. Reddy, Tamil Iniyan Gunasekaran et al.
2 citations
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
0.49
article

ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease

Nastasia Nelson, Giuseppe Tosto, Joseph S. Reddy, Tamil Iniyan Gunasekaran, Mehmet İlyas Coşacak, Caghan Kizil, Özkan İş, Yuhao Min, Hüseyin Tayran, Zikun Yang, Andrew F. Teich, Elanur Yılmaz, Nilüfer Ertekin‐Taner, Richard P Mayeux, Prabesh Bhattarai, Xue Wang, Badri Narayan Vardarajan, Dolly Reyes‐Dumeyer, Rüya Merve Dogru, Nada Kassara, Min N Qiao, Yiyi Ma, Delaney Flaherty
article en
2 citations

Abstract

Our results demonstrate a previously unknown link between ABCA7 and NPY in regulation of synaptic integrity and neurogenesis in AD. We propose that ABCA7-dependent NPY is a resilience factor in vertebrate brains, and this reserve mechanism is impaired in AD.

Alzheimer s & DementiaVol. 20(S1)
NewYork–Presbyterian Hospital (US), Columbia University Irving Medical Center (US), New York Hospital Queens (US), German Center for Neurodegenerative Diseases (DE), WinnMed (US), Institute on Aging (US), Mayo Clinic in Florida (US), Columbia University (US)
Openalex Percentile: Top 32%
Neuroinflammation and Neurodegeneration Mechanisms
0.49
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