Sex Modulates the Influence of APOE Genotype on Sleep and Sleep‐Dependent Memory Consolidation in Older Adults
Our study reveals that the interplay of sex and APOE affects sleep patterns and memory consolidation in older adults. Notably, distinct non-rapid eye movement (NREM) sleep stages impact Slow Delta and Theta Modulation (SDMC) differently in male and female APOE ε4-carriers. While enhanced sleep quality may mitigate APOE and sex-related cognitive decline in later life, considering sex-related differences in memory benefits from sleep is crucial for older adults at high risk for AD.
Authors
- Negin Sattari (ORCID: https://orcid.org/0000-0002-3974-9030)
- Bryce A. Mander (ORCID: https://orcid.org/0000-0002-0831-7980)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Kitty K. Lui (ORCID: https://orcid.org/0000-0001-7586-0118)
- Miranda G Chappel-Farley (ORCID: https://orcid.org/0000-0003-1349-0507)
- Kate E. Sprecher (ORCID: https://orcid.org/0000-0002-7918-7108)
- Abhishek Dave (ORCID: https://orcid.org/0000-0002-6186-027X)
- Ruth M. Benca (ORCID: https://orcid.org/0000-0002-5895-817X)
- Brady A. Riedner (ORCID: https://orcid.org/0000-0002-8393-1737)
Institutions
- University of Wisconsin–Madison (US)
- University of California, Irvine (US)
- San Diego State University (US)
- University of California San Diego (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090492
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00